DETERMINATION OF NEOSTIGMINE AND PYRIDOSTIGMINE IN THE URINE OF PATIENTS WITH MYASTHENIA GRAVIS
نویسندگان
چکیده
منابع مشابه
Clinical pharmacology of pyridostigmine and neostigmine in patients with myasthenia gravis.
Determination of plasma concentration of pyridostigmine in 20 myasthenic patients on maintenance therapy revealed rather small intraindividual variations within a dose interval. The predose concentration varied considerably between different patients and up to seven fold in patients on the same daily dose. No pharmacokinetic interaction between pyridostigmine and neostigmine was found in five p...
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A case of myasthenia gravis in a 15 years old girl is pre·sented. The disease was present for 5 years before thymectomy was performed. Indications for thymectomy, preoperative preparation, anesthetic and surgical management is -discussed.
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CONTEXT Patients with myasthenia gravis receive pyridostigmine, an anticholinesterase agent, as a part of therapy. These patients demonstrate a heightened sensitivity towards non-depolarising muscle relaxants. Continuing pyridostigmine till the day of the surgery or omitting it on the night before surgery could provide variable results with regards to the effect of vecuronium. AIMS Myographic...
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The relationship between plasma levels of pyridostigmine to clinical evaluation of muscle power was examined in nine patients with myasthenia gravis during treatment with pyridostigmine in doses of 60 to 1040 mg daily. Five of the nine subjects demonstrated a trend towards a positive correlation, but in only two of them was this statistically significant at p < 0.05. In addition, the presence o...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1962
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1962.tb01181.x